{"id":2332,"date":"2024-05-24T20:44:55","date_gmt":"2024-05-24T11:44:55","guid":{"rendered":"https:\/\/www.soyokazesogo.com\/blog\/?p=2332"},"modified":"2024-05-24T21:23:01","modified_gmt":"2024-05-24T12:23:01","slug":"%e7%8c%ab%e4%bc%9d%e6%9f%93%e6%80%a7%e8%85%b9%e8%86%9c%e7%82%8e%e3%81%ae%e6%b2%bb%e7%99%82","status":"publish","type":"post","link":"https:\/\/www.soyokazesogo.com\/blog\/%e7%8c%ab%e4%bc%9d%e6%9f%93%e6%80%a7%e8%85%b9%e8%86%9c%e7%82%8e%e3%81%ae%e6%b2%bb%e7%99%82\/","title":{"rendered":"\u732b\u4f1d\u67d3\u6027\u8179\u819c\u708e\u306e\u6cbb\u7642"},"content":{"rendered":"<h1>\u732b\u4f1d\u67d3\u6027\u8179\u819c\u708e\u306e\u6cbb\u7642\uff1a\u5e0c\u671b\u3068\u6311\u6226<\/h1>\n<h2>\u732b\u4f1d\u67d3\u6027\u8179\u819c\u708e\u3068\u306f\uff1f<\/h2>\n<p>\u732b\u4f1d\u67d3\u6027\u8179\u819c\u708e\uff08FIP\uff09\u306f\u3001\u732b\u306b\u304a\u3051\u308b\u81f4\u547d\u7684\u306a\u30a6\u30a4\u30eb\u30b9\u6027\u75be\u60a3\u3067\u3001\u732b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08FCoV\uff09\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002FCoV\u306f\u4e00\u822c\u7684\u306b\u7121\u5bb3\u3067\u3059\u304c\u3001\u4e00\u90e8\u306e\u732b\u3067\u306f\u7a81\u7136\u5909\u7570\u3092\u8d77\u3053\u3057\u3001FIP\u306b\u9032\u884c\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u75c5\u6c17\u306f\u8179\u90e8\u3084\u80f8\u90e8\u306b\u6db2\u4f53\u304c\u305f\u307e\u308a\u3001\u5168\u8eab\u306b\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n<h2>FIP\u306e\u75c7\u72b6<\/h2>\n<p>FIP\u306b\u306f\u6e7f\u6f64\u578b\u3068\u4e7e\u71e5\u578b\u306e2\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u3002\u30a6\u30a8\u30c3\u30c8\u578b\u3067\u306f\u3001\u8179\u90e8\u3084\u80f8\u90e8\u306b\u6db2\u4f53\u304c\u305f\u307e\u308a\u3001\u8179\u90e8\u81a8\u6e80\u3084\u547c\u5438\u56f0\u96e3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u30c9\u30e9\u30a4\u578b\u3067\u306f\u3001\u8178\u3084\u809d\u81d3\u306a\u3069\u306e\u5185\u90e8\u5668\u5b98\u306b\u708e\u75c7\u304c\u5e83\u304c\u308a\u3001\u767a\u71b1\u3001\u98df\u6b32\u4e0d\u632f\u3001\u4f53\u91cd\u6e1b\u5c11\u306a\u3069\u306e\u75c7\u72b6\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u3069\u3061\u3089\u306e\u578b\u3082\u9032\u884c\u304c\u65e9\u304f\u3001\u81f4\u6b7b\u7387\u304c\u9ad8\u3044\u306e\u304c\u7279\u5fb4\u3067\u3059\u3002<\/p>\n<h2>\u4f1d\u7d71\u7684\u306a\u6cbb\u7642\u6cd5<\/h2>\n<p>\u5f93\u6765\u306eFIP\u6cbb\u7642\u306f\u5bfe\u75c7\u7642\u6cd5\u304c\u4e2d\u5fc3\u3067\u3042\u308a\u3001\u75c7\u72b6\u306e\u8efd\u6e1b\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u6297\u751f\u7269\u8cea\u3084\u6297\u708e\u75c7\u85ac\u3001\u5229\u5c3f\u85ac\u306a\u3069\u304c\u4f7f\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u306e\u305f\u3081\u3001\u591a\u304f\u306e\u7363\u533b\u5e2b\u304c\u5b89\u697d\u6b7b\u3092\u9078\u629e\u305b\u3056\u308b\u3092\u5f97\u306a\u3044\u72b6\u6cc1\u3067\u3057\u305f\u3002<\/p>\n<h2>\u65b0\u3057\u3044\u6cbb\u7642\uff1aGS-441524<\/h2>\n<p>\u8fd1\u5e74\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85acGS-441524\u304cFIP\u6cbb\u7642\u306b\u304a\u3044\u3066\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u85ac\u306f\u3001FIP\u306e\u539f\u56e0\u3068\u306a\u308b\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u3092\u963b\u5bb3\u3057\u3001\u9ad8\u3044\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u591a\u304f\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u3001GS-441524\u3092\u4f7f\u7528\u3057\u305f\u732b\u306e\u591a\u304f\u304c\u5b8c\u5168\u306b\u56de\u5fa9\u3057\u305f\u4f8b\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<div class=\"py-2 juice:py-[18px] px-3 text-base md:px-4 m-auto md:px-5 lg:px-1 xl:px-5\">\n<div class=\"mx-auto flex flex-1 gap-3 text-base juice:gap-4 juice:md:gap-6 md:max-w-3xl lg:max-w-[40rem] xl:max-w-[48rem]\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex-col gap-1 md:gap-3\">\n<div class=\"flex flex-grow flex-col max-w-full\">\n<div class=\"min-h-[20px] text-message flex flex-col items-start whitespace-pre-wrap break-words [.text-message+&amp;]:mt-5 juice:w-full juice:items-end overflow-x-auto gap-2\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"1a937992-d9c3-459f-bbee-5d85bb4cff3f\">\n<div class=\"flex w-full flex-col gap-1 juice:empty:hidden juice:first:pt-[3px]\">\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\n<p>GS-441524\u306f\u3001\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5927\u5b66\u30c7\u30fc\u30d3\u30b9\u6821\uff08UC Davis\uff09\u306eNiels Pedersen\u535a\u58eb\u3068\u305d\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306b\u3088\u3063\u3066\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u3082\u3068\u3082\u3068\u306f\u3001\u30a8\u30dc\u30e9\u30a6\u30a4\u30eb\u30b9\u6cbb\u7642\u85ac\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u3044\u305fRemdesivir\u306e\u524d\u99c6\u7269\u8cea\u3067\u3059\u3002FIP\u306e\u539f\u56e0\u3067\u3042\u308b\u732b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3001\u732b\u3067\u306e\u6cbb\u7642\u306b\u8ee2\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u7814\u7a76\u306e\u7d50\u679c\u3001GS-441524\u304cFIP\u306e\u6cbb\u7642\u306b\u975e\u5e38\u306b\u52b9\u679c\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3001\u73fe\u5728\u3067\u306f\u591a\u304f\u306e\u732b\u306e\u547d\u3092\u6551\u3046\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u200b <span class=\"\" data-state=\"closed\"><span class=\"text-token-text-secondary\">(<\/span><a class=\"text-green-600 !no-underline\" href=\"https:\/\/www.vet.cornell.edu\/research\/awards\/202312\/elucidating-antiviral-mechanism-gs-441524-and-developing-novel-therapeutic-targets-feline-infectious\" target=\"_blank\" rel=\"noopener noreferrer\">Cornell Vet<\/a><span class=\"text-token-text-secondary\">)<\/span><\/span>\u200b\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"w-full text-token-text-primary\" dir=\"auto\" data-testid=\"conversation-turn-12\" data-scroll-anchor=\"false\">\n<div class=\"py-2 juice:py-[18px] px-3 text-base md:px-4 m-auto md:px-5 lg:px-1 xl:px-5\">\n<div class=\"mx-auto flex flex-1 gap-3 text-base juice:gap-4 juice:md:gap-6 md:max-w-3xl lg:max-w-[40rem] xl:max-w-[48rem]\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col\">\n<div class=\"flex-col gap-1 md:gap-3\">\n<div class=\"flex flex-grow flex-col max-w-full\">\n<div class=\"min-h-[20px] text-message flex flex-col items-start whitespace-pre-wrap break-words [.text-message+&amp;]:mt-5 juice:w-full juice:items-end overflow-x-auto gap-2\" dir=\"auto\" data-message-author-role=\"user\" data-message-id=\"aaa26cc5-0b52-4508-abba-2e52ae83d868\">\n<div class=\"flex w-full flex-col gap-1 juice:empty:hidden items-end rtl:items-start\">\n<div class=\"w-full text-token-text-primary\" dir=\"auto\" data-testid=\"conversation-turn-13\" data-scroll-anchor=\"false\">\n<div class=\"py-2 juice:py-[18px] px-3 text-base md:px-4 m-auto md:px-5 lg:px-1 xl:px-5\">\n<div class=\"mx-auto flex flex-1 gap-3 text-base juice:gap-4 juice:md:gap-6 md:max-w-3xl lg:max-w-[40rem] xl:max-w-[48rem]\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex-col gap-1 md:gap-3\">\n<div class=\"flex flex-grow flex-col max-w-full\">\n<div class=\"min-h-[20px] text-message flex flex-col items-start whitespace-pre-wrap break-words [.text-message+&amp;]:mt-5 juice:w-full juice:items-end overflow-x-auto gap-2\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"53acb7b4-5dfa-46a8-a1b9-06a9738e10f4\">\n<div class=\"flex w-full flex-col gap-1 juice:empty:hidden juice:first:pt-[3px]\">\n<h3>\u30e1\u30ab\u30cb\u30ba\u30e0<\/h3>\n<p>GS-441524\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u306eRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u3092\u963b\u5bb3\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u3092\u59a8\u3052\u308b\u3053\u3068\u3067\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u611f\u67d3\u306e\u9032\u884c\u3092\u6291\u3048\u3001\u732b\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u75c5\u6c17\u3068\u6226\u3046\u306e\u3092\u52a9\u3051\u307e\u3059\u200b<span class=\"\" data-state=\"closed\"><span class=\"text-token-text-secondary\"> (<\/span><a class=\"text-green-600 !no-underline\" href=\"https:\/\/www.vet.cornell.edu\/research\/awards\/202312\/elucidating-antiviral-mechanism-gs-441524-and-developing-novel-therapeutic-targets-feline-infectious\" target=\"_blank\" rel=\"noopener noreferrer\">Cornell Vet<\/a><span class=\"text-token-text-secondary\">)<\/span><\/span>\u200b\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h2>GS-441524\u306e\u5165\u624b\u3068\u6cbb\u7642\u306e\u73fe\u72b6<\/h2>\n<p>GS-441524\u306f\u73fe\u5728\u3001\u4e00\u90e8\u306e\u56fd\u3067\u5229\u7528\u53ef\u80fd\u3067\u3059\u304c\u3001\u6b63\u5f0f\u306a\u85ac\u4e8b\u627f\u8a8d\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u5165\u624b\u304c\u96e3\u3057\u3044\u72b6\u6cc1\u3067\u3059\u3002\u7363\u533b\u5e2b\u306e\u6307\u5c0e\u306e\u4e0b\u3067\u6cbb\u7642\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u9055\u6cd5\u306b\u53d6\u5f15\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308b\u305f\u3081\u3001\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u98fc\u3044\u4e3b\u306f\u4fe1\u983c\u3067\u304d\u308b\u60c5\u5831\u6e90\u304b\u3089\u85ac\u3092\u5165\u624b\u3057\u3001\u7363\u533b\u5e2b\u3068\u5bc6\u306b\u9023\u643a\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n<h2>\u6cbb\u7642\u306b\u304b\u304b\u308b\u30b3\u30b9\u30c8\u3068\u6642\u9593<\/h2>\n<p>GS-441524\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u9ad8\u984d\u306a\u8cbb\u7528\u304c\u304b\u304b\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u6cbb\u7642\u671f\u9593\u306f\u901a\u5e3812\u9031\u9593\u7a0b\u5ea6\u3067\u3001\u6bce\u65e5\u306e\u6ce8\u5c04\u304c\u5fc5\u8981\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7d4c\u6e08\u7684\u304a\u3088\u3073\u6642\u9593\u7684\u306a\u8ca0\u62c5\u304c\u5927\u304d\u3044\u3053\u3068\u304c\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2>\u98fc\u3044\u4e3b\u304c\u3067\u304d\u308b\u3053\u3068<\/h2>\n<p>FIP\u3068\u8a3a\u65ad\u3055\u308c\u305f\u5834\u5408\u3001\u98fc\u3044\u4e3b\u3068\u3057\u3066\u3067\u304d\u308b\u3053\u3068\u306f\u3001\u65e9\u671f\u767a\u898b\u3068\u8fc5\u901f\u306a\u6cbb\u7642\u958b\u59cb\u304c\u9375\u3067\u3059\u3002\u307e\u305f\u3001\u30b9\u30c8\u30ec\u30b9\u3092\u6e1b\u3089\u3057\u3001\u514d\u75ab\u529b\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u9069\u5207\u306a\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u3082\u91cd\u8981\u3067\u3059\u3002\u3055\u3089\u306b\u3001\u4fe1\u983c\u3067\u304d\u308b\u7363\u533b\u5e2b\u3068\u306e\u9023\u643a\u3092\u5f37\u5316\u3057\u3001\u6700\u65b0\u306e\u6cbb\u7642\u6cd5\u3084\u60c5\u5831\u3092\u5e38\u306b\u628a\u63e1\u3057\u3066\u304a\u304f\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n<h2>\u672a\u6765\u306e\u5c55\u671b<\/h2>\n<p>FIP\u6cbb\u7642\u306f\u307e\u3060\u591a\u304f\u306e\u8ab2\u984c\u304c\u3042\u308a\u307e\u3059\u304c\u3001GS-441524\u306e\u3088\u3046\u306a\u65b0\u3057\u3044\u85ac\u306e\u958b\u767a\u306b\u3088\u308a\u3001\u591a\u304f\u306e\u732b\u304c\u6551\u308f\u308c\u308b\u53ef\u80fd\u6027\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001\u3088\u308a\u591a\u304f\u306e\u7814\u7a76\u304c\u9032\u307f\u3001\u5b89\u5168\u3067\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u304c\u666e\u53ca\u3059\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2>\u304a\u308f\u308a\u306b<\/h2>\n<p>\u732b\u4f1d\u67d3\u6027\u8179\u819c\u708e\u306f\u6050\u308d\u3057\u3044\u75c5\u6c17\u3067\u3059\u304c\u3001\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u767b\u5834\u306b\u3088\u308a\u3001\u5e0c\u671b\u304c\u898b\u3048\u59cb\u3081\u3066\u3044\u307e\u3059\u3002\u611b\u732b\u306e\u5065\u5eb7\u3092\u5b88\u308b\u305f\u3081\u306b\u3001\u98fc\u3044\u4e3b\u3068\u3057\u3066\u5e38\u306b\u6700\u65b0\u306e\u60c5\u5831\u3092\u53ce\u96c6\u3057\u3001\u9069\u5207\u306a\u5bfe\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n<div class=\"py-2 juice:py-[18px] px-3 text-base md:px-4 m-auto md:px-5 lg:px-1 xl:px-5\">\n<div class=\"mx-auto flex flex-1 gap-3 text-base juice:gap-4 juice:md:gap-6 md:max-w-3xl lg:max-w-[40rem] xl:max-w-[48rem]\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex-col gap-1 md:gap-3\">\n<div class=\"flex flex-grow flex-col max-w-full\">\n<div class=\"min-h-[20px] text-message flex flex-col items-start whitespace-pre-wrap break-words [.text-message+&amp;]:mt-5 juice:w-full juice:items-end overflow-x-auto gap-2\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"1a937992-d9c3-459f-bbee-5d85bb4cff3f\">\n<div class=\"flex w-full flex-col gap-1 juice:empty:hidden juice:first:pt-[3px]\">\n<div class=\"markdown prose w-full break-words dark:prose-invert light\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"w-full text-token-text-primary\" dir=\"auto\" 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